Home Behandelprotocollen HIT Richtlijnen en literatuur


Er is op dit moment geen richtlijn voor HIT.


  1. Schols SEM en Eikenboom HCJ. Hoe behandel in heparine-geïnduceerde trombocytopenie? Nederlands Tijdschrift voor Hematologie, jaargang 14, nr 4, 06-2017
  2. Greinacher A. Heparin-Induced Thrombocytopenia. N Engl J Med 2015;373(3):252-261
  3. McGowan KE, Makari J, Diamantouros A et al. Reducing the hospital burden of heparin-induced thrombocytopenia: impact of an avoid-heparin program. Blood 2016;127(16):1954-1959
  4. Arepally GM and Ortel T. Heparin-Induced Thrombocytopenia. Annu Rev Med 2010;61:77-90
  5. McKenzie SE and Sachais BS. Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia. Curr Opin Hematol 2014;21(5):380-387
  6. Tutweiler V, Madeeva D, Sook Ahn H et al. Platelet transactivation by monocytes promotes thrombosis in heparin-induced-thrombocytopenia. Blood 2016;127(4):464-472
  7. Lee GM and Arepally GM. Diagnosis and Management of Heparin-Induced Thrombocytopenia. Hematol Oncol Clin North AM 2013;27(3):541-563
  8. Lo GK, Juhl D, Warkentin TE, et al. Evaluation of pretest clinical score (4 T’s) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost 2006;4:759-765
  9. Rondina MT, Walker A and Pendleton RC. Drug-induced Thrombocytopenia for the Hospitalist Physician with a focus on Heparin-Induced Thrombocytopenia. Hosp pract (1995) 2010;38(2):19-28
  10. Linkins L, Bates SM, Lee AYY et al. Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study. Blood 2015;126(5):597-603
  11. Arnold DM and Kelton JG. Testing for heparin-induced thrombocytopenia: are we there yet? J Thromb Haemost 2007;5:1371-1372
  12. Pouplard C, Gueret P, Fouassier M, et al. Prospective evaluation of the `4Ts’ score and particle gel immunoassay specific to heparin/PF4 for the diagnosis of heparin induced thrombocytopenia. J Thromb Haemost 2007; 5:1373–1379
  13. Warkentin TE, Arnold DM, Nazi I et al. The platelet serotonin-release assay. Am J Hematol 2015; 90(6): 564-572
  14. Eichler P, Budde U, Haas S et al. First workshop for detection of heparin-induced antibodies: validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4/heparin ELISA. Thromb Haemost 1999:81(4):625-629
  15. Cuker A and Cines DB. How I treat heparin-induced thrombocytopenia. Blood 2012;119(10):2209-2218
  16. Linkins L, Dans AL, Moores LK, et al. Treatment and Prevention of Herapin-Induced Thrombocytopenia. Antithrombotic Therapy and Prevention of Thrommbosis, 9th ed: American College of Chest Physicians Evidence-based Clinical Practice Guidelines. Chest 2012;141(2):e495S-e530S
  17. Warkentin TE, Greinacher A, Koster A et al. Treatment and prevention of heoarin-induced thrombocytopenia : American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008 ;133 :6 Suppl : 340S-380S
  18. Kang M, Alahmadi M, Sawh S et al. Fondaparinux for the treatment of suspected heparin-induced thrombocytopenia : a propensity scorematched study. Blood 2015 :125 :924-929
  19. Chong BH, gallus AS, Cade JF, et al. Prospective randomised open-label comparison of danaparoid with dextran 70 in the treatment of heparin-induced thrombocytopaenia with thrombosis: a clinical outcome study. Thromb Haemost 2001;86(5):1170-1175
  20. Walenga JM, Prechel M, Jeske WP et al. Rivaroxaban – an oral Walenga JM, Prechel M, Jeske WP, et al. Rivaroxaban­an oral, direct Factor Xa inhibitor­has potential for the management of patients with heparin-induced thrombocytopenia. Br J Haematol 2008; 143:92
  21. Refaai MA, Chuang C, Menegus M, Blumberg N, Francis CW. Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia. J Thromb Haemost 2010 Jun;8(6):1419-21
  22. Tardy-Poncet B, Piot M, Montmartin A, et al. Delayed-onset heparin-induced thrombocytopenia without thrombosis in a patient receiving postoperative thromboprophylaxis with rivaroxaban. Thromb Haemost 2015; 114:652
  23. Ho PJ and Siordia JA. Dabigatran approaching the realm of heparin-induced thrombocytopenia. Blood research 2006; 51(2):77-87
  24. Shatzel JJ, Crapster-Pregont M, Deloughery TG. Non-vitamin K antagonist oral anticoagulants for heparin-induced thrombocytopenia. A systematic review of 54 reported cases. Thromb Haemost 2016; 116:397
  25. Warkentin TE and Anderson JAM. How I treat patients with a history of heprain-induced thrombocytopenia. Blood 2016;128(3):348-359
  26. Badger NO. Fondaparinux (Arixtra®), a safe alternative for the treatment of patients with herapin-induced thrombocytopenia? Journal of Pharmacy Practice 2010;23(3):235-238


Ga terug naar de HIT homepage of lees meer over HIT:

Ga terug naar de algemene homepage Behandelprotocollen.