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Acute myeloïde leukemie (AML)

HOVON 150: A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy

Chronische myeloïde leukemie (CML)


Muscle function: The relation between muscle function and muscle pain in patients with chronic myeloid leukemia (CML): a pilot study

CMyLife effectmeting: The impact of CMyLife on quality of life, information supply, patient empowerment and guideline and medication adherence in patients with CML

Zorgpad analyse CML: Pathways of care that lead to a sustained and deep treatment response in chronic myeloid leukemia

Myelodysplastisch syndroom (MDS)


EU-MDS: A prospective, multicentre European registry for newly diagnosed patients with myelodysplastic syndromes (MDS), including acute myeloid leukaemia with 20-30 percent marrow blasts (former RAEB-t), and chronic myelomonocytic leukaemia (CMML)

COMMANDS: A phase 3, open-label, randomized study to compare the efficacy and safety of luspatercept (ACE-536) versus epoetin alfa for the treatment of anemia due to IPSS-R very low, low or intermediate risk myelodysplastic syndromes (MDS) in ESA naïve subjects who require red blood cell transfusions 

Myeloproliferatieve neoplasieën (MPN)


HOVON 134: A phase II trial in patients with myelofibrosis (primary, post-ET or post-PV-MF) treated with the selective JAK2 inhibitor pacritinib before reduced-intensity conditioning allogeneic stem cell transplantation

Non-Hodgkin lymfomen (NHL)


HOVON 119: Efficacy of alternating immunochemotherapy consisting of R-CHOP + RHAD versus R-CHOP alone, followed by maintenance therapy consisting of additional lenalidomide with rituximab versus rituximab alone for older patients with mantle cell lymphoma

HOVON 127: Phase III study comparing R-CODOX-M/R-IVAC versus dose-adjusted EPOCH-R (DA-EPOCH-R) for patients with newly diagnosed high risk Burkitt lymphoma

HOVON 133 / TRIANGLE: Autologous transplantation after a rituximab/ibrutinib/ara-c containing induction in generalized mantle cell lymphoma – A randomized European MCL network trial

HOVON 136: Phase I-II study combining brentuximab vedotin with second line salvage chemotherapy (R-DHAP) in CD30 positive diffuse large B-cell lymphoma patients refractory to first line chemotherapy or in first relapse who are eligible for high dose treatment followed by autologous stem cell transplantation

HOVON 152: A phase II study evaluating the effect of DA-EPOCH-R induction followed by nivolumab consolidation in patients with newly diagnosed high grade B cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements

Multipel myeloom (MM)


HOVON 114: Pomalidomide combined with carfilzomib and dexamethasone (PCd) for induction and consolidation followed by pomalidomide combined with dexamethasone vs pomalidomide maintenance for patients with multiple myeloma in first relapse after prior 1st line treatment with lenalidomide and bortezomib

NivoDara: A phase 2 study of nivolumab combined with daratumumab with or without low-dose cyclophosphamide in relapsed/refractory multiple myeloma

Stamceltransplantatie (SCT)


PSCT19: Vaccination with PD-L1/L2-silenced minor histocompatibility antigen-loaded donor DC vaccines to boost graft-versus-tumor immunity after allogeneic stem cell transplantation (a phase I/II study)

Auto-immuun hemolytische anemie (AIHA)


DRAIHA: Data registry of autoimmune hemolytic anemia, to improve diagnostic testing for the development of personalized treatment protocols in AIHA patients

Supportive care


ORASTEM: Oral complications in patients treated with hematopoietic stem cell transplantation

AzoR-Man: PCR based detection of azole resistance in A. fumigatus to improve patient outcome. A prospective multicentre intervention study

AFFECT-2: Efficacy of interleukin-1 pathway inhibitor anakinra for the management of fever during neutropenia and mucositis in patients with multiple myeloma receiving an autologous hematopoietic stem cell transplantation after high-dose melphalan

Transfusiegeneeskunde


PACER: A randomized controlled trial on prophylactic platelet transfusion prior to central venous catheter placement in patients with trombocytopenia

BITE: A nationwide epidemiological and laboratory case cohort study investigating risk factors for bleeding in hemato-oncology patients

Stolling


PRO-RBDD: Prospective data collection on patients with rare bleeding disorders

RBiN: Rare bleeding disorders in the Netherlands

HemoNED: Landelijk register van patiënten met hemofilie en aanverwante aandoeningen

EUHASS: European haemophilia safety surveillance system registry

OPTI-CLOT: Peri-operative pharmacokinetic-guided dosing of clotting factor in hemophilia

DAVID: DDAVP treatment combined with FVIII clotting factor concentrates in patients with mild hemophilia A

Little DAVID: Desmopressin and FVIII concentrate combination treatment in non-severe hemophilia A patients undergoing minor interventions

HiN-6: Haemophilia in the Netherlands 6

Obizur EU PASS: Prospective, non-interventional study to evaluate the safety and effectiveness of Obizur in real-life practice

DYNAMICS: The Dynamic interplay between bleeding phenotype and baseline factor level in moderate and mild hemophilia A and B

PRIDES:
Observational study on pregnancy outcome in women with inherited bleeding disorders

Hemoglobinopathie


STARRING: Sickle cell disease: targeting alloantibody formation reduction; risk factors, and genetics

Paroxysmale nachtelijke hemoglobinurie (PNH)


RPNH01: Paroxysmal nocturnal hemoglobinuria (PNH) registry

AK581: Akari long term safety coversin

DAHLIA / ABP959: A randomized, double-blind, active-controlled phase 3 study evaluating the efficacy and safety of ABP 959 compared with eculizumab in adult subjects with paroxysmal nocturnal hemoglobinuria (PNH)


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