Myelodysplastisch syndroom (MDS)
COMMANDS: A phase 3, open-label, randomized study to compare the efficacy and safety of luspatercept (ACE-536) versus epoetin alfa for the treatment of anemia due to IPSS-R very low, low or intermediate risk myelodysplastic syndromes (MDS) in ESA naïve subjects who require red blood cell transfusions
Chronische myeloïde leukemie (CML)
HOVON 142: Sustained treatment-free remission in BCR-ABL+ chronic myeloid leukemia: a prospective study comparing nilotinib versus imatinib with switch to nilotinib in absence of optimal response
Non-Hodgkin lymfomen (NHL)
HOVON 136: Phase I-II study combining brentuximab vedotin with second line salvage chemotherapy (R-DHAP) in CD30 positive diffuse large B-cell lymphoma patients refractory to first line chemotherapy or in first relapse who are eligible for high dose treatment followed by autologous stem cell transplantation
HOVON 152: A phase II study evaluating the effect of DA-EPOCH-R induction followed by nivolumab consolidation in patients with newly diagnosed high grade B cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements
Auto-immuun hemolytische anemie (AIHA)
DRAIHA: Data registry of autoimmune hemolytic anemia, to improve diagnostic testing for the development of personalized treatment protocols in AIHA patients
Stolling
BITE: A nationwide epidemiological and laboratory case cohort study investigating risk factors for bleeding in hemato-oncology patients
SLIM: Shared medical appointments to change lifestyles of overweight hemophilia patients
Paroxysmale nachtelijke hemoglobinurie (PNH)
DAHLIA / ABP959: A randomized, double-blind, active-controlled phase 3 study evaluating the efficacy and safety of ABP 959 compared with eculizumab in adult subjects with paroxysmal nocturnal hemoglobinuria (PNH)
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