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Acute myeloïde leukemie (AML)

HOVON 156: A phase 3, multicenter, open-label, randomized study of gilteritinib versus midostaurin in combination with induction and consolidaton therapy followed by one-year maintenance in patients with newly diagnosed acute myeloid leukemia (AML) or myelodysplastic syndromes with excess blasts-2 (MDS-EB2) with FLT3 mutations eligible for intensive chemotherapy

Myelodysplastisch syndroom (MDS)

IMerge 2: A study to evaluate imetelstat (GRN163L) in transfusion-dependent subjects with IPSS low or intermediate-1 risk myelodysplastic syndrome (MDS) that is relapsed/refractory to erythropoiesis-stimulating agent (ESA) treatment

Myeloproliferatieve neoplasieën (MPN)

FREEDOM 2: A phase III, multi center, open-lable, randomized study to evaluate the efficacy and safety of fedratinib compared to best avaiable therapy in subjects with DIPSS-intermediate or high-risk primary myelofibrosis, post-polycytemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis and previously treated with ruxolitinib 

Supportive care

REDDS2: A randomised feasibility n-of-1 trial of weekly-interval red cell transfusion in myelodysplastic syndromes

CLARITY: Cardiotoxicity and other late effects after radiotherapy and immuno-chemotherapy for non-Hodgkin lymphoma

DUET2: Azole-echinocandin combination therapy for invasive aspergillosis. A randomized pragmatic superiority trial


SCORE: Sickle cell outcome research

SICKLE CELL SCREEN: Investigating red blood cell deformability of sickle cell patients before and after the start of therapy

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